How does coffee wake us up (and why is it addictive)? – FlipScience


coffee, caffeinecoffee, caffeine

Julius Schorzman

•Coffee keeps us awake and helps us focus because of its caffeine content.
•Caffeine is a stimulating drug that interferes with adenosine and the brain, preventing us from getting sleepy.
•Consuming too much caffeine can cause some nasty side effects, and can even make you dependent on the substance. 


Whether it’s to pull an all-nighter for a project due the next day or to shake that terrible feeling of grogginess in the morning, many of us have relied on a good, old cup of joe (or two) to keep ourselves awake and focused.

It’s no secret that people across the world depend on this drug—yes, you read that right, and we’ll get into that in a bit—to help them get through their day-to-day existence.

Coffee (and the stuff that’s in it) can help you focus, keep you active, and let you do what you need to do. Wondering how it accomplishes that? Read on.

What caffeine actually does to your brain

Before anything else, yes, caffeine (the stimulant found in beverages like coffee, cocoa, and energy drinks) is a drug. It’s classified as such because, by definition, a drug is a substance that can alter or affect one’s physical and mental state: two things that caffeine achieves.

In the process of consuming energy from breaking down adenosine triphosphate (ATP) molecules to accomplish our daily tasks, adenosine is left behind. Neurons in our brains have specialized receptors where adenosine can fit in snugly. When activated, these receptors work to inhibit the neurons, slowing down the release of molecules that control brain activity, making us drowsy in the process. Additionally, adenosine binding causes the blood vessels in our brains to dilate; this increases our oxygen intake while we’re asleep. Thus, adenosine acts as a regulatory chemical that manages our sleep cycle.

Now, when we ingest food, drinks, and other substances that contain caffeine, it disrupts this natural sequence of our molecules in our heads telling us to rest. This is because caffeine has a molecular structure similar enough to adenosine’s that our brains aren’t able to tell the two apart.

The caffeine finds its way to the receptors that would normally host adenosine. However, it doesn’t actually bind to (or activate) them. Instead, it simply blocks the latter from making us sleepy, and keeps us awake and alert for longer periods of time.

Giving way for other molecules

When adenosine binds to the receptors that slow down neurons, it can also make it harder for other compounds like dopamine, a chemical responsible for eliciting and promoting pleasure, from fitting into their own spots because of the size of its molecule.

As such, when caffeine replaces it, the dopamine has better wiggle room to fit into their own receptors. This causes us to experience elevated moods in the process. (This is similar to the effect of cocaine and heroin, albeit to a much…



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